DRUG PROFILE OF PIROXICAM

PRESENTED TO:
Dr. Samreen Faisal

PRESENTED BY:
Ahad Nawaz

Pharm-D 4th Prof

Contents
Introduction
Product Description
Chemistry of Drug
Pharmacokinetics
Clinical Pharmacology
Dosage Schedule
Precautions
Side Effects
Administration Guidelines
Drug-drug Interactions
Drug Food Interactions
Therapeutic Drug Monitoring
Toxicology
References

Introduction
Generic Name: Piroxicam

Drug Category: Prescribed

National Essential Drug List: Present

WHO Essential Drug List: Present

Product Description

Feldene
Generic: Piroxicam
Dosage form: Tab/Cap/Gel/Inj
Available strength:
10- 20mg/0.5%w/w& 20mg/ml
Manufactured By: Pfizer

Oricam
Generic: Piroxicam
Dosage form: Tab & Cap
Available strength:10-20mg
Manufactured By: Axis Pharma

Diodex
Generic: Piroxicam
Dosage form: Tab/Cap & Gel
Available strength: 20mg/ 0.5% w/w
Manufactured by: Pearl Pharma

CHEMISTRY OF DRUG
Chemical class:
Enolic acid derivative
Chemical Nature:
Acidic
Molecular formula/weight:
C15H13N3O4S / 331.35

Physical Properties:
Off-white to yellow crystalline powder
Melting Point is198° to 200°c

Pharmacokinetics

Absorption
Piroxicam is absorbed completely after oral administration and undergoes enterohepatic circulation.
Peak concentrations in plasma occur within 3-5hours

Distribution
Bioavailability:
65-90%
Protein Binding:
99%
Blood Brain Barrier:
Not cross the BBB
Secreted in Milk:
Yes
Volume of Distribution:
0.14L/kg

Elimination

Clinical Pharmacology

Dosage Schedule

Rheumatoid Arthritis

Route of Administration:
Oral / Parenteral
Recommended Dose:
20mg Once daily
Duration of Therapy:
7 to 12 Days

Osteoarthritis


Route of Administration:
Oral / Parenteral
Recommended Dose:
20mg Once daily
Duration of Therapy:
7 to 12 Days

Ankylosing Spondylitis

Route of Administration:
Oral / Parenteral
Recommended Dose:
20mg Once daily
Duration of Therapy:
7 to 12 Days

Juvenile Rheumatoid Arthritis

Route of Administration:
Oral / Parenteral
Recommended Dose:
5-15mg Once daily according
to body weight of the child
Duration of Therapy:
5 to 8 Days

Side Effects
GI disturbances including
Discomfort, Nausea, Diarrhoea, Heartburn, bleeding& Ulceration.

Rash, Dizziness, Tinnitus

Hepatic damage

Alveolitis, Pulmonary eosinophilia, Apnea

Dyspepsia, Increase bleeding time

Storage
Keep medicine out of the reach of children.

Store in a dry place,
Protect from sunlight and
moisture

Store below 30°C

Precautions
Piroxicam should be used with caution in patients with coagulation defects &

Patients on anticoagulant therapy.

Discontinue drug if skin reaction occurs.

Administration Guidelines


Give with milk, antacids, or food to
minimize GI upset.

Drug-Drug Interactions

Drug-Food Interactions
Piroxicam have not shown any
food interaction.

Therapeutic Drug Monitoring
NSAIDs have the wide therapeutic index so due to this reason they don’t require therapeutic drug monitoring

Toxicology

REFERENCES
Basic & Clinical Pharmacology_
Bertram_G._Katzung- 9th Edition Page 823

Goodman & Gillman's Manual of Pharmacology &
therapeutics-2008 Page-453

BNF 61st Edition Page-639

Clarke's Analysis of Drugs and Poisons 3rd Edition Page-521